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Family history is a strong indication that one or more family members will be affected by hyperhidrosis. As evidenced through many peer reviewed clinical papers, more than 51% of patients have traces of family history, suggesting there is a strong genetic factor to hyperhidrosis. Hyperhidrosis can skip generations, and the severity of hyperhidrosis varies from one patient to another.

Age of onset represents a significant characteristic, with primary hyperhidrosis typically beginning during childhood or adolescence.

Severity classifications help identify patient subgroups. Mild cases may involve occasional dampness, while severe hyperhidrosis can result in dripping sweat that interferes with daily activities. The Hyperhidrosis Disease Severity Scale provides standardized measurements for these characteristics.